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In contrast, 55% of PD patients had Lewy microsomes in the mucosa and submucosa, with the detection of Lewy fibers in submucosal biopsies of the rectum as well as the ascending and descending colon in 2365% of PD patients

Several genes of chromosome 21 are directly implicated in oxidative stress, involving Cu, Zn-SOD (SOD1), ETS2 (ETS Proto-Oncogene 2) transcription factor, stress-inducible factor, protein S100, Down syndrome critical region gene 1 (DSCR1), amyloid precursor protein (APP), the -site APP cleaving enzyme 1 (BACE1) (Antonarakis et al

The enzyme noted above, cholesterol 7-alpha-hydroxylase, is the enzyme responsible for the initial step in the catabolism of cholesterol to conjugated bile acids

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