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Intravenous administration bypasses the digestive tract, where oral glutathione largely breaks down, so the full dose reaches the blood

Sia, D., Villanueva, A., Friedman, S

doi: 10.1212/WNL.31.12.1557 86

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It has, however, proven difficult thus far to demarcate the CNS consequences of SCFA-mediated effects on intestinal barrier function from a direct action in the brain