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Nevertheless, transcriptional modifications may also lead to delays in recovery, as ongoing perturbations on a transcriptional level were observed for up to 6 months after infection, with PASC patients showing a distinct profile, such as upregulation of the alarmins S100A8 and HMGB1, mediators and markers of innate immune activation (124)

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Twenty-five women with lipedema had significant improvements in pain, tension in the legs, excessive warmth, muscle cramps, leg heaviness, tired legs, swelling, itching, general involvement of the skin, difficulty walking, quality of life, and appearance of the legs six months post-liposuction surgery (104)

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