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An alternative cause of "atrophic" hypothyroidism is the development of thyroid stimulation blocking antibodies (TSBAb), which, as the name implies, prevent TSH binding to TSH-R, but do not stimulate thyroid cells and produce hypothyroidism

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In clinical studies, volunteers in the higher dose groups such as 8 mg or 12 mg experienced reductions in body weight and waist circumference, up to 19.2% at week 48

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