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Some, but not all, studies have reported that HIF activation can decrease the content of mitochondria in cells, which offers a plausible explanation for the known decrease in cellular respiration in response to hypoxia (Figure 2A)

PUFAs inhibit the p38MAPK inflammatory pathway, which modulates microglia activity, thus inhibiting cytokine release and neuroinflammation

The generation of ROS leads to lipid peroxidation, mitochondrial dysfunction, and DNA fragmentation, which collectively contribute to cell death in the inner ear (Ramkumar et al

Age is also associated with GSH levels, where GSH concentrations decrease as age increases in erythrocytes and mammals [73]

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