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Here are the major medication classes that deplete glutathione and most doctors never mention this when they write the prescription: NSAIDs (Advil/ibuprofen, Aleve/naproxen, aspirin, Celebrex) the same over-the-counter pain relievers most people grab without thinking Acetaminophen-containing painkillers Vicodin, Percocet, Norco, Darvocet, NyQuil, Excedrin PM these combine acetaminophen with other drugs, doubling the depletion Acid blockers/PPIs Prilosec, Nexium, Prevacid, Zantac suppress stomach acid, impair nutrient absorption, and tax the liver Antibiotics broad-spectrum antibiotics disrupt gut flora and increase oxidative stress Cholesterol medications (statins) deplete CoQ10 and glutathione simultaneously Chemotherapy drugs massive glutathione depletion by design Tricyclic antidepressants processed through the liver, depleting glutathione in the process As pharmacist Suzy Cohen puts it: Any medication that goes through your liver can increase your requirements for glutathione