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Description

It works as a signaling molecule, telling your cells to do certain things

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This FGF8 signaling cascade subsequently activates Wnt1 expression in the midbrain, which in turn upregulates the Engrailed-1/2 transcription factorsfirst detected at embryonic days 11.514 in micewhereupon their sustained expression becomes essential for the maintenance and survival of VTA DA neurons (Hegarty et al., 2013)