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We validated the impact of CENPT-GCLC on GSH synthesis, resulting in a decrease in lipid peroxidation and ROS levels, mediating RCC ferroptosis resistance and proliferation

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We showed that MAPL, a SUMO E3 ligase present in mitochondria, can promote the SUMO1 modification of Drp1, facilitate its mitochondrial translocation and induce detrimental fission, leading to mitochondrial dysfunction, NPC apoptosis, and IVDD