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However, as the development and testing of remyelination-based therapies requires effective model systems with sustained demyelination and lack of complete endogenous remyelination, we conclude that 1 mM CPZ treatment of brain slice cultures is not a viable ex vivo model for these studies, however, could prove to be useful in acute demyelination studies, pending further characterization

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Moreover, amino acids, such as tryptophan metabolites, have been shown to function as a key class of immunomodulatory mediators capable of regulating immune homeostasis in MS (7983)

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