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10.1016/j.jhep.2014.09.033 82

Macrophages and mast cells clear damaged tissue and cellular debris, while secreting proteins essential for wound contraction and overall tissue healing

Adults with mild to moderate knee osteoarthritis confirmed on imaging Inadequate relief from first-line conservative care: physical therapy, weight management, NSAIDs, activity modification No active joint infection No known allergy to hyaluronic acid products Not appropriate for or not yet ready for surgical evaluation Patients with end-stage knee OA (bone-on-bone on imaging) typically respond less well to viscosupplementation

By contrast, GDIL overexpression enhance cytoplasmic translocation of XRN2 in parental CRC cells, while this effect could be blocked when overexpressed GDIL with fragment 1 (1200 nt) deleted (Fig