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Inhibition of SHMT2 by SHIN1 leads to NADH depletion under hypoxia, which in turn results in the accumulation of the TCA cycle intermediate oxaloacetate and aspartate

Such stress adversely affects germination, vegetative growth, reproductive organ development, enzymatic activity, photosynthesis photostability, and hormonal equilibrium, eventually causing oxidative stress and drastic loss of crop yield

More recently, one study showed the modulation by lactate of the action potential frequency in pyramidal cells from the CA1 region of the hippocampus, under stable energetic conditions

NeuroSense Therapeutics plans to file for early commercialization of ALS treatment in Canada

It is important to monitor neurological symptoms closely when initiating Dpenicillamine or trientine treatment because these can cause paradoxical neurological decline, especially if dosing is too aggressive (initial dose too high or dose increase too rapid)