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In melanocytes 4-HNE, through adduct formation, alters protein function, contributing to oxidative stress-induced cellular dysfunction, which mainly concerns on the functioning of cellular antioxidant system, acceleration of protein degradation, inhibition of melanocyte proliferation, photoaging processes, but also disruption of the intercellular interactions between melanocytes and keratinocytes 101,102,103

Cell signaling: H2O2, a necessary evil for cell signaling

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Consistently, beneficial effects of Sirt3 have also been observed in myocardial I/R injury (95)