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Chronic stress reduces EAAT2 expression in the prefrontal cortex and hippocampus, increasing excitatory neurotransmission and promoting hyperarousal [88]

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APS altered its composition, enhancing the variety of GM, leading to the reduction in the relative prevalence of Pseudoflavonifractor and Parapovella and the increase of Parabacteroides, Parasutterella, Butyricicoccus, Clostridium perfringens XIVb, and Dorea

Typically, this has been carried out either through the use of error-prone PCR (as described in Moore, J., et al, Nature Biotechnology 14:458, (1996), or through the application of randomized synthetic oligonucleotides corresponding to specific regions of interest (as described by Derbyshire, K