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81 , 119 (1959) Meldrum, N.U.: The reduction of glutathione in mammalian erythrocytes

While the molecular pathogenesis of AxD remains incompletely understood, massive reactive astrogliosis with Rosenthal fibers composed of aggregated GFAP, vimentin, nestin, B-crystallin and small heatshock proteins together with prominent leukodystrophy are the pathological hallmarks, with the pathophysiological picture including mitochondrial malfunction, redox imbalance and susceptibility to oxidative stress 331,332,333

When mitochondrial function is compromised by oxidative stress, cellular processes slow down, leading to decreased collagen production, impaired barrier function, and reduced skin hydration

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Effects of two-year Vitamin B (12) and folic acid supplementation on depressive symptoms and quality of life in older adults with elevated homocysteine concentrations: additional results from the B-PROOF study, an RCT