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Specifically this makes individuals susceptible to reoccurring infections by catalase positive organisms

Moreover, although the unmethylated CpGs of lipoplex systems are masked preventing an innate immune response, once they are in the general circulation, lipoplex systems may be, similarly like polyplex systems, opsonized by blood proteins (C3, IgG, lipoproteins and fibronectin) resulting in inflammatory reactions (mediated by TNF-alpha, IL-6 and IL- 12) in lungs and liver

CYPs may also catalyze demethylation to aflatoxin P (AFP 1 ) of the parent AFB 1 molecule, resulting in products less toxic than AFB 1