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Olaparib treatment also replenished NAD + levels, enhanced mitochondrial function, and promoted fatty acid oxidation, thereby reversing non-alcoholic fatty liver disease (NAFLD) in mice fed a high-fat, high-sucrose diet 164 (Fig

First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate

Serotonin reuptake inhibition: Enhances satiety signals Reduces appetite Improves mood (reduces emotional eating) Stabilizes cravings Similar to SSRIs but different profile Potency ratios: Why triple inhibition powerful: Attacks weight loss from multiple angles Metabolic + appetite + behavioral changes Synergistic effects stronger than single pathway But also multiplies side effect risks Different from GLP-1 single mechanism Compare to semaglutide mechanism and other weight loss approaches