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This trajectory is the reverse of the differentiation that occurs during melanocyte development, where undifferentiated tissue in the embryonic neural plate give rise to highly migratory and mesenchymal neural crest cells, some of which differentiate into melanocytes upon reaching the epidermis ( Figure 1 The similarity between EMT and de-differentiation programs extends beyond cell-intrinsic alterations and impacts cell-extrinsic changes as well

Cherry blossom extract is also one of the ingredients found in Bright Circulist supplement which can help to lighten hyperpigmentation and promote even skin tones

For patients with clinical improvement, further doses of hydroxocobalamin were given weekly in the following 1 to 3 weeks

So far, it seems to be a good choice

Majernkov N, Jia J, Andrea Y