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Oxidative stress primarily refers to the process of oxidative damage resulting from an imbalance between oxidative and antioxidant systems in cells and tissues, leading to the accumulation of free radicals and ROS (41)

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Tosic M, Ott J, Barral S, Bovet P, Deppen P, Gheorghita F, et al

10.1016/s0006-291x(00)90000-7 [DOI] [PubMed] [Google Scholar] Harms N., Ras J., Reijnders W

Research has shown that alcohol stimulates hepatocytes to release extracellular vesicles containing CD40L in a caspase-3-dependent manner [167], thereby activating macrophages and increasing the production of inflammatory cytokines