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After applying eligibility criteria and excluding studies with methodological limitations or insufficient relevance, 107 articles were included in this review

The results showed that EGCG treatment significantly increased RXR mRNA expression, which correlated with a marked reduction in methylation levels at the RXR promoter

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Lentiviral gene transduction The shRNA sequence against SRD5A1, that is CTCGAGTGCTGTTGACAGTGAGCGACCTGTACCTGTTATCAATATATAGTGAAGCCACAGATGTATATATTGATAACAGGTACAGGCTGCCTACTGCCTCGGAGAATTC, was cloned into TRIPZ vector (Thermo Fisher Scientific, USA), which provides inducible shRNA expression in the presence of doxycycline (Dox)