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Because the peptide occurs naturally in human plasma (at roughly 200 ng/mL in young adults, declining to approximately 80 ng/mL by age 60), topical supplementation essentially restores youthful local concentrations in treated skin

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Metabolic Regulation and Energy Homeostasis Research Broader metabolic regulation research including studies on energy substrate utilisation, fatty acid oxidation, mitochondrial function in adipocytes, and the molecular basis of metabolic flexibility, has drawn on this compound as a research tool