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Smoking and risk for diabetes incidence and mortality in Korean men and women

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Metabolic: Hyperglycemia advanced glycation end-products (AGEs), polyol pathway activation, oxidative stress, mitochondrial dysfunction nerve ischemia and axon loss in diabetic neuropathy per ADA Standards of Care

The abundance of D-serine is determined by both the degrading enzyme D-amino acid oxidase (DAO), which shows high expression in the hindbrain, where D-serine levels are low, and the synthetic enzyme serine racemase that generates D-serine from L-serine (Schell et al., 1995