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When damage occurs, it is often possible for the mitochondria to undergo membrane permeability transition and release proapoptotic proteins

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For example, gene therapy has been used to reduce P-gp expression at the BBB, and RNA interference (RNAi) technology has been employed to silence the P-gp gene [86]

Although numerous studies have documented the therapeutic potential of SE for various diseases, to the best of our knowledge, we are the first to investigate the anti-neuroinflammatory and anti-amnesic effects of desalted and enzyme-digested SE ethanol extract (SE-EE)

However, this process depends on several cofactors, including vitamin C, iron, and B vitamins