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Figure 4 Macrophages are the key mediators by which monoclonal antibodies to play a therapeutic role, and antibodies targeting CD38 will also affect macrophage function ( Summary and Prospects CD38 has dual functions, acting as an extracellular enzyme and a surface receptor

Depending on pH conditions, CD38 catalyzes the conversion of NAD + to adenosine (ADO), a mediator of calcium signaling that promotes tumor survival and immune evasion