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We found that processing the counts from the 2 cohorts together and correcting for batch effects with ComBat effectively harmonized the data from the 2 cohorts

[DOI] [PubMed] [Google Scholar] 87.Lee H.R., Jeong Y.J., Lee J.W., Jhun J., Na H.S., Cho K.H., Kim S.J., Cho M.L., Heo T.H

The escalation phases are only required during the first cycle

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Also, 6,7,4'-trihydroxyisoflavone was identified as a potent competitive inhibitor of monophenolase activity of tyrosinase by Chang et al., with an IC 50 value of 9.2 M, which is six times potent than kojic acid 258