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Site 5 is far away from the catalytic site, and the compound binding does not cause any significant conformational variation, except the shift of the side chains of Leu73 and Phe83 in the case of hit 90 (Supplementary Figure S2B), suggesting that the binding of these ligands may not affect TbTR activity

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An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway