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Limited human observations corroborate a favorable short-term tolerability profile, usually involving mild, transient reactions such as localized injection-site irritation or temporary gastrointestinal discomfort

[16] Thanks According to some studies, using ice before an injection will reduce the pain, but it wont make a significant difference regarding bruising

Key Points The insulin-like growth factor 1 ( IGF1 ) gene is a major target of growth hormone IGF1 binds the IGF1 receptor (IGF1R) with high affinity and the insulin receptor with low affinity