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M., Kasemo, B

O., Gascoyne, R

321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury

Some of these target serotonin in the brain to treat migraines directly, while others are used to treat individual symptoms

Within four to six hours after ischemia onset, circulating leukocytes adhere to vessel walls and migrate into the brain with subsequent release of additional pro-inflammatory mediators and secondary injury in the penumbra