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The sample size was calculated to be 130 according to the OpenEpi sample size calculator website, with a two-sided significance level (1-) of 0.95, 0.8 power, a ratio of exposed/unexposed of 0.6, and an assumed odds ratio of 3

Voice change or hoarseness: Especially important for cancers of the voice box

While the retail price per pack of cigarettes is highest in Tobacco Nation at $5.48 per pack, the percentage of an average persons income spent per pack is quite low, when compared to these 10 low- and middle-income countries. Framing it in this context, cigarette prices in Tobacco Nation are relatively cheap, and Tobacco Nation residents are more financially able to purchase a pack of cigarettes than residents in countries such as India, Indonesia, Brazil and Mexico

Today, they remain a niche product preferred by smokers who enjoy a more traditional smoking experience

Highlight the addictive nature of nicotine and the potential long-term health effects