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The C-terminus residue and its side chains interact with R289 and N345, respectively

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In particular, proximal tubular epithelial cells express CYP27B1, which converts circulating 25-hydroxyvitamin D [25(OH)D] into its biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)D]

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Preclinical work provides mechanistic insight, like peptide-driven cell proliferation and angiogenesis, clarifying both repair and risk

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When they detect a threat, they degranulate, releasing a flood of inflammatory mediators, including histamine, cytokines, and leukotrienes

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