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In a rat model of CP-induced POF, LVM significantly reduced ovarian oxidative damage, inflammation, and apoptosis via suppression of the TLR4/p38 MAPK/NF-B and Bax/Bcl-2/caspase-3 pathways, in addition to the activation of the -Klotho protein pathway (Rofaeil et al

10.1016/j.pain.2003.11.005 Pain 21 GouldenN.KhusnulinaA.DavisN

Figure 4a showed that rhGPx3 mutant was superimposed on U46C GPx4 mutant (PDB entry 2OBI) with a root mean square deviation of 2.87 , for 156 C-Alpha atoms