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Involvement of OCTN2 and B0,+ in the transport of carnitine through an in vitro model of the blood-brain barrier

The safest and most effective outcomes occur when therapy is guided by specialists, monitored closely, and combined with healthy lifestyle interventions

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LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

The antibody itself must also be optimized: it should bind strongly to the target and internalize efficiently, and it should be engineered (often humanized or fully human) to avoid immune rejection by the patient