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The breadth of documented activity reflects what the original investigators have described as systems-level pharmacology: rather than acting through a single high-affinity receptor, BPC-157 appears to modulate multiple intersecting cellular pathways including nitric oxide signalling, growth-factor receptor expression, dopamine and serotonin metabolism, and angiogenic vessel formation

This work was supported by a grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR052308) to B.S.T

After reconstitution, the solution should be kept refrigerated at 2 to 8 C, with working dilutions prepared immediately before use and filter-sterilized through a 0.22 m low-protein-binding filter for sterile cell culture

10.1111/vco.12102 384 LucarelliM.VisalberghiE.AdrianiW.AddessiE.PierandreiS.MancioccoA.et al

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