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1 Adverse reactions that occurred in 2% of patients treated with RADICAVA and 2% more frequently in placebo-treated patients 1 Hypersensitivity reactions and cases of anaphylaxis have been reported in postmarketing reports with RADICAVA 1 Discontinuations were not associated with contusion, gait disturbance, or headache in patients treated with RADICAVA 2 No known drug interactions based on in vitro drug interaction studies 1 RADICAVA ORS Was Generally Well Tolerated 1,3 The safety profile of RADICAVA ORS was demonstrated in a 6-month, phase 3, open-label clinical trial in 185 patients

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Turkovic et al., 2004), resistant to L-NAME, even in conditions when L-arginine does not work, which has some physiologic importance (Sikiric et al., 1997

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FIGURE 3 TPPU and DHA + TPPU Decrease Inflammation in the Hippocampus of Diabetic Rats An increase in the neuroinflammation was evident in the hippocampus of diabetic rats due to the rise in the level of pro-inflammatory marker IL-1 (Figure 4A) (412 29 pg/ml) and IL-6 (Figure 4B) (180 6 pg/ml) and decrease in the level of anti-inflammatory marker IL-10 (Figure 4C) (220 7 pg/ml) in comparison to the healthy normal rats (IL-1, 311 14 pg/ml