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In addition, the CTH inhibitor has off-target activity (33, 40)

here, we mainly summarize the role of the gut microbiota in specific parts of the skeleton (such as the femur and vertebrae)

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Additionally, betaine exhibits strong antioxidant and anti-inflammatory capabilities, alleviating oxidative damage by reversing GSH depletion, increasing MDA levels, reducing vitamin A content, and inhibiting cytochrome p450 family 2 subfamily E member 1 expression and hydroxytaurine production (113, 119)