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Science 357 , 661667 (2017)

Activation of the IGF-1 receptor's tyrosine kinase domain by IGF-1 initiates IRS phosphorylation, which triggers the PI3K signaling cascade

The cell division cycle-dissociated protein 4 (CDCA4) knock-down by RNA interference in MCF-7 human breast cancer cell lines resistant to Adriamycin (MCF-7/ADM) decreased the percentage of cancer cells by 50%