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Abstract Glutathione S -transferase alpha 4 (GSTA4) is a phase II detoxifying enzyme that is overexpressed in colorectal cancer (CRC) and regulated by the oncogenic transcription factor AP-1

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Of these enzymes, CD38, PARPs and SARM1 appear to significantly contribute to cellular NAD degradation [1-4, 6, 19, 28, 34-39]

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