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This is derived primarily from sugar cane and is an alpha hydroxy acid b

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One aspect of this function, however, is the inhibition of deacetylases such as tubulin deacetylase in the case of MTs and histone deacetylase 6 (HDAC6) in the case of heterochromatin (Perez et al., 2009)

However, a major challenge is its poor oral bioavailability: Curcumin is hydrophobic, unstable at physiological pH, and undergoes rapid first-pass metabolism (Tabanelli et al., 2021

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