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When viewed along the carbon-carbon bond using a Newman projection, the hydrogen atoms of one methyl group can adopt different orientations relative to those of the other methyl group

Although istradefylline was associated with a significantly higher risk of dyskinesia compared to placebo (RR = 1.72, 95% CI = 1.26 to 2.34, p = 0.0007), no significant differences were observed for mild adverse reactions such as tremor, nausea, constipation, hallucinations, insomnia, somnolence, or accidents

One study used molecular dynamics simulation tools to investigate the impact of 4 forms of last-generation graphene-based nanostructures on preventing -synuclein amyloid fibrillation

Several metals and metalloproteins, such as iron, copper, chromium, and cobalt, also contribute to the generation of reactive species, primarily through Fenton-like reactions [9,10]

Neuropharmacology 177 , 108247 (2020)