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Consistently, intestinal-specific overexpression of TXNIP abolished metformin-induced improvements in glucose tolerance, while pharmacological inhibition of GLUT1 similarly negated metformins glucose-lowering effects

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Cipolla-Neto J, Amaral FGD

Glutathione plays a crucial role in protecting cells from oxidative stress, which is implicated in the pathogenesis of many diseases, including neurodegenerative disorders, cardiovascular diseases, and liver diseases