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Results SIRT1 expression and activity is downregulated following noise exposure To systematically explore the impact of acoustic trauma on SIRT1 in mouse cochlear hair cells, 5-week-old C57BL/6 J mice were subjected to noise at 108 dB SPL for 2 h, based on a previously demonstrated protocol to induce NIHL in mouse models [28]

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however, in phase 1 clinical trial, BIIB078 failed to exert meaningful effects on CNS pathologies and had no significant impact on neurofilament levels but paradoxically increased inflammatory marker CCL26, and its development has been discontinued (van den Berg et al., 2024

[Google Scholar] 28.Platt R

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