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The NewcastleOttawa quality assessment scale was performed to assess the qualities of the included studies (eTable 2)

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However, these efforts have predominantly focused on disease-specific applications, leaving broader population-wide strategies underdeveloped

Sci Transl Med 3(70):70ra13 Guevara-Aguirre J et al (2015) GH receptor deficiency in Ecuadorian adults is associated with obesity and enhanced insulin sensitivity

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