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Based on this study alone, the FDA initially declined approval, but reversed its decision several months later

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Whether their heterogeneity and different response levels to CD38 mAb in patients contribute to different outcomes following Daratumumab therapy requires more evidence (Figure 5) [55]

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Lenert A, Fardo DW

The main advantages of this strategy are to improve the physicochemical stability of drugs, increase their bioavailability and optimize their pharmacokinetic properties, so as to exert the therapeutic effect of drugs more effectively [49,50,51]