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Direct comparison of MG toxicity in primary cultures of mouse cortical neurons and astrocytes evidenced a 6-fold higher susceptibility toward MG toxicity in neurons compared to astrocytes (Blanger et al., Neuronal MG toxicity is associated with AGEs production and accumulation (Blanger et al., 2008

The up-regulated gene list contained a number of glutathione depletionresponsive genes reported previously, such as Trib3, Srxn1, Myc, Asns, Igfbp1, Txnrd1, or Hmox1, suggesting that these genes are robust mRNA biomarkers for evaluating hepatic glutathione depletion

Injection Method: Administered intravenously (IV) once a week

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