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Wrist joint pain is often something that starts mildly but can soon become extremely debilitating

10.1038/s41401-020-00568-2 70 LiuH.AnN.WangL.LiY.SongK.SunY.et al (2023e)

Hedgehog inhibits -catenin activity in synovial joint development and osteoarthritis[J]

Immunostaining results revealed a notable increase in the expression of the histone variant H2AX, which is a known marker for DNA double-strand breaks (DSBs)