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The problem:- No clear global guidelines for screening vit B12 deficiency in Metformin treated patients

Some of the symptoms of a vitamin B12 deficiency may include: Fatigue Weakness Memory loss Cognitive functioning problems Diarrhea or constipation Loss of appetite Shortness of breath Beefy, red, smooth and sore tongue Sore mouth and/or bleeding gums Numbness and tingling of hands and feet Poor sense of balance Depression Confusion Insomnia Vision problems Loss of hearing and tinnitus Pale, possibly yellowish pallor in light-skinned individuals

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For prophylaxis of meningeal leukemia, the usual dose is 12-15mg, administered intrathecally

A CTNNB1-altered medulloblastoma shows the immunophenotypic, DNA methylation and transcriptomic profiles of SHH-activated, and not WNT-activated, medulloblastoma