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Mutat Res 375:18, PMID: 9129674 Weitzman SA, Turk PW, Milkowski DH, Kozlowski K (1994) Free radical adducts induce alterations in DNA cytosine methylation

The mechanisms by which IGF-I reverses and/or prevents microvascular rarefaction and improves tissue blood supply are likely multifaceted, and may involve, among others: 1) Apoptosis, since IGF-I inhibits oxidative stress-induced apoptosis by preserving the functional integrity of the mitochondria[56, 290]