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Expert Rev Gastroenterol Hepatol 11(9):813819 Heidrich B et al (2018) Intestinal microbiota in patients with chronic hepatitis C with and without cirrhosis compared with healthy controls

doi: 10.1001/jamapsychiatry.2015.1737 90

Targeting Dark Spots and Hyperpigmentation Glutathione can contribute significantly to reducing dark spots and hyperpigmentation by inhibiting tyrosinase activity during melanogenesis

Promising results have also been reported by two recent studies of metformin in combination with TKIs and ICIs, respectively, which suggested that metformin was able to significantly improve PFS and OS in patients with NSCLC by overcoming acquired resistance to TKIs and enhancing PD-1 blockade by anti-PD-1 antibodies, respectively (101,102)