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Most studies involve small participant numbers, short follow-up periods, and lack robust placebo controls, limiting the strength of conclusions

Mixing them creates stability and degradation issues that compromise the efficacy of both compounds

However, in T2D pathology, insulin resistance and excessive free radical production act as synergistic mediators of pathological liver conditions such as hepatic ischemia, hepatic cirrhosis, non-alcoholic fatty liver disease, obstructive cholestasis, and hepatocellular carcinoma[]