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From the results obtained in vivo, it is also possible to verify that the reduction in PD-L1 levels facilitates the infiltration of CD4 + T cells and CD8 + T cells into tumor, culminating in a reduction in tumor growth

10.1016/j.bmc.2006.09.053 52

Therefore, a comprehensive understanding of the complex mechanisms of these two types of metabolic cell death is highly important for the development of therapeutic targets in the field of oncology