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Related studies mainly focus on in vivo intervention efficacy validation, exploration of combined intervention strategies, and optimization of pharmaceutical dosage forms, providing important experimental evidence for clinical intervention of obesity

Each drug hits certain pathways and there are clues there: Nicotine and stimulants - acetylcholine and glutamate (so maybe reduced glutamate, to begin with) Benzos - GABA (so maybe too much glutamate) Alcohol - GABA and serotonin (plus just about everything) a depressant so too much glutamate